Effective Pre-workout Supplements for Energy

Analyzing effectiveness of pre-workout supplements to distinguish between beneficial and overrated products in fitness.

What Works and What’s Just Hype?

Pre-workout supplements are a worldwide popular tool to enhance performance, endurance, and focus in all types of physical activity. They are widely available and advertised. However, the overwhelming number of options on the market can confuse even those serious about fitness.

Very often, it can be difficult to distinguish between what works and what is just clever marketing. That’s why this article explores the science behind pre-workout supplements. We aim to separate the effective ingredients from those that are more about hype than results.

What is the purpose of pre-workout supplements?

The idea behind pre-workout supplements is to improve workout performance. This can be done by increasing energy, endurance, and focus. That’s why these supplements are often formulated as a mix of:

  • Stimulants
  • Amino acids
  • Vitamins
  • Other compounds (aimed at priming the body for exercise)

However, not all ingredients are backed by strong scientific evidence. It is not uncommon for some formulations to include unnecessary or even harmful additives.

Which pre-workout supplements work?

So, what does the science say? It is not simple to answer this question with all the marketing “buzzing” in the fitness supplements world. It’s (understandably) even more difficult for amateurs and workout enthusiasts with little knowledge of biochemistry, medicine, nutrition, etc. Luckily, we did our homework. Here’s an overview of science-backed pre-workout supplements:

1. Caffeine

Caffeine is one of the most widely studied and proven performance enhancers. It stimulates the central nervous system, increasing alertness, reducing perceived exertion, and improving endurance. Studies have shown that moderate doses (150-300 mg) taken thirty to sixty minutes before exercise can enhance both aerobic and anaerobic performance. But there’s a downside too. Excessive caffeine intake can lead to jitters, insomnia, and increased heart rate.

2. Creatine Monohydrate

Creatine is one of the most researched and effective supplements for increasing strength and power. It helps replenish ATP (adenosine triphosphate). ATP is the primary energy currency of cells that helps to improve performance in high-intensity exercises. Unlike caffeine, creatine does not provide an immediate boost but works over time with consistent supplementation (3-5 grams daily).

3. Beta-Alanine

Beta-alanine is an amino acid that helps buffer acid buildup in muscles. It delays fatigue and improves endurance, especially in high-intensity, short-duration activities. A tingling sensation (paresthesia) is a common side effect, but it is harmless. A dose of 2-5 grams per day, taken consistently, is necessary to see benefits.

4. L-Citrulline (or Citrulline Malate)

L-citrulline is an amino acid that enhances nitric oxide production, promoting vasodilation (widening of blood vessels) and improving blood flow. This can lead to better oxygen and nutrient delivery to muscles, potentially enhancing endurance and reducing muscle soreness. A dose of 6-8 grams of citrulline malate is commonly used in pre-workout formulas.

5. Branched-Chain Amino Acids (BCAAs)

BCAAs, like leucine, isoleucine, and valine are popular for their role in muscle recovery and reducing muscle soreness. While they may provide some benefits for endurance and muscle preservation, those consuming sufficient protein throughout the day may not need extra BCAA supplementation.

6. Nitrate (Beetroot Extract)

Nitrate, found in beetroot and other vegetables, has been shown to improve exercise efficiency and endurance by increasing nitric oxide levels. This leads to better oxygen utilization, particularly in endurance activities. A dose of 300-600 mg of nitrate (or about 500 ml of beetroot juice) before exercise can enhance performance.

Which ingredients are more hype than science?

Many popular pre-workout supplements are more hype than science. Here’s a more detailed look:

1. Arginine

While arginine is often included in pre-workouts for its role in nitric oxide production, citrulline is far more effective at increasing blood levels of arginine and promoting vasodilation. Arginine itself has poor bioavailability and does not significantly enhance performance.

2. Taurine

Taurine is often marketed as an endurance booster. However, research on its effectiveness in pre-workouts is inconclusive. While it may have some benefits for hydration and electrolyte balance, it does not significantly enhance performance.

3. Glutamine

Glutamine is frequently added to pre-workout supplements, but research suggests that it has little impact on muscle growth or workout performance for individuals who already consume adequate protein.

4. Proprietary Blends

Many pre-workouts contain proprietary blends, which group multiple ingredients without disclosing specific amounts. This makes it difficult to determine if key ingredients are dosed effectively. Companies may use this tactic to include cheap filler ingredients while making bold claims about their effectiveness.

5. Excessive Stimulants

Stimulants do not necessarily mean better performance. Some pre-workouts contain an overload of stimulants beyond caffeine, such as yohimbine or synephrine, which can lead to negative side effects like:

  • Increased heart rate
  • Anxiety
  • Digestive discomfort

How to choose a quality pre-workout supplement?

This is what you should look for when selecting a pre-workout supplement:

Transparent labeling

Avoid proprietary blends and look for products that clearly list ingredient amounts.

Clinically effective dosages

Research-backed doses matter more than just the ingredient list.

Minimal artificial additives

Some pre-workouts contain excessive artificial sweeteners, colors, or unnecessary fillers.

Caffeine content

If you are sensitive to caffeine, opt for a lower dose or a stimulant-free pre-workout.

Can I make my pre-workout formula?

The short answer is yes. The DIY approach to pre-workout is possible. It is suitable for individuals who prefer a more natural (no artificial preservatives or fillers) or budget-friendly approach. You can make your pre-workout by combining key ingredients. A simple, effective DIY pre-workout might include:

  • 200 mg caffeine (from coffee or caffeine pills)
  • 5 g creatine monohydrate
  • 6-8 g citrulline malate
  • 3-5 g beta-alanine
  • A small amount of fruit juice for taste and carbohydrates

The Bottom Line

Not all pre-workout supplements are created equal. Some contain ingredients with strong scientific backing, while others rely on marketing gimmicks and underdosed proprietary blends. By understanding which ingredients are effective and which are merely hype, you can make informed choices that enhance your workouts without wasting money on ineffective products. Whatever you choose to do, always prioritize evidence-based ingredients to maximize performance and achieve your fitness goals.

Dr. Rosmy Barrios is a physician specializing in regenerative and aesthetic medicine. She serves as the Medical Director of the Regenerative Medicine Department at P.A.R.K.S Clinic. With over a decade of international experience, Dr. Barrios focuses on anti-aging therapies, cellular regeneration, and holistic wellness. She is also a published health writer and advisor, contributing to platforms like Forbes and Yahoo Health, and is a member of several global aesthetic medicine associations.